Track: 25, Arbovirus pathogenesis and development of innovative vaccine candidates
prof. dr. Eric Snijder
dr. Martijn van Hemert, dr. Marjolein Kikkert
dr. Barry Rockx (Erasmus MC)
My research sits within the work packages aiming to provide an integrated approach to intervention development. More specifically the goals of this project are to characterise the phenotypes of Usutu Virus (USUV) variants using reverse genetics, based on both rational design and variants identified in field studies. The mutants will be studied to assess their transmissibility, virulence and immune evasion capabilities and the molecular determinants involved. Results from these studies will be applied to create attenuated designs for use in a range of vaccine platforms. The scope of this project also includes using these tools to study West Nile Virus (WNV), and the potential to incorporate other arboviruses with risks of emergence in line with a proactive one health approach.
Research questions / objectives